Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir.

Ona Barauskas,Amoreena C Corsa,Ruth Wang,Scott Hluhanich,Debi Jin,Magdeleine Hung,Huiling Yang,William E Delaney,Brian E Schultz

Biochimica et Biophysica Acta (BBA) - General Subjects（2014）

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摘要

•GS-9256 and vedroprevir are potent inhibitors of hepatitis C virus NS3 protease.•The compounds have high selectivity against off-target mammalian proteases.•GS-9256 and vedroprevir display one-step binding with rapid association kinetics.•The biochemistry of GS-9256 and vedroprevir supports their use in clinical trials.

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关键词

CatD,CatL,HCV,HLE,PPE,Pr3

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