Metadata beyond the sequence enables the phylodynamic inference of bovine viral diarrhea virus type 1a isolates from Western Canada

Infection, Genetics and Evolution(2014)

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摘要
•We infer the evolution of BVDV type 1a in Western Canada.•BVDV 1a in Western Canada has a most recent common ancestor dated near 1909.•The E1-E2 gene region has a much higher substitution rate than the 5′UTR.•Genetic clusters are associated with collection location.•Bayesian approaches allow the integration of metadata beyond the genetic sequence.
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关键词
BVDV,Phylodynamics,Bayesian,Evolution,Most common recent ancestor,Model selection
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