Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.

Kishore K Chiruvella,Brian M Renard,Shanda R Birkeland,Sham Sunder,Zhuobin Liang,Thomas E Wilson

DNA Repair（2014）

引用 5|浏览7

暂无评分

摘要

•A mutational screen of the yeast DNA ligase IV BRCT domains is reported.•NHEJ efficiency and the Dnl4–Lif1 interaction (LIG4-XRCC4 in humans) were examined.•A separation of function suggesting multiple roles of the BRCT domains was observed.•Dnl4 BRCT1 supported NHEJ in a manner distinct from Lif1 interaction.

查看译文

关键词

BRCT,ChIP,DSB,GAL1-cs,MRX,NHEJ,PCR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要