Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function

Leonid A Pobezinsky,Ruth Etzensperger, Susanna Jeurling,Amala Alag,Tejas Kadakia,Tom M McCaughtry,Motoko Y Kimura,Susan O Sharrow,Terry I Guinter,Lionel Feigenbaum,Alfred Singer

NATURE IMMUNOLOGY（2015）

引用 118|浏览20

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摘要

Singer and colleagues show that let-7 microRNAs target Zbtb16 mRNA, which encodes the transcription factor PLZF, to modulate PLZF expression during the terminal differentiation of NKT cells into effector subsets.

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nature immunology, science

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