Inhibition of bacterial mevalonate diphosphate decarboxylase by eriochrome compounds.

D Andrew Skaff,William J McWhorter,Brian V Geisbrecht,Gerald J Wyckoff,Henry M Miziorko

Archives of Biochemistry and Biophysics（2015）

引用 4|浏览7

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摘要

•Mevalonate pathway enzymes as drug targets in Gram-positive bacteria.•Mevalonate diphosphate decarboxylase (MDD) inhibition by drug-like compounds.•NCI Mechanistic Diversity Set compound library screening.•Eriochromes A, B, and T as S. epidermidis MDD inhibitors.

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关键词

Mevalonate diphosphate decarboxylase,Mevalonate pathway,Isoprenoid biosynthesis,Enzyme inhibitors

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