Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study.
Gynecologic Oncology(2015)
摘要
•We examine whether variation in gonadotropin signaling pathway genes is associated with ovarian cancer risk.•We evaluate individual SNP effects and gene-level effects through burden testing using the admixture likelihood (AML) method.•Four putative ovarian cancer susceptibility loci near INHBB, LHCGR, GNRH, and FSHB are identified.
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关键词
Ovarian cancer,Gene,Gonadotropins,Genetics,Polymorphisms,Genetic variation
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