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ATG14 controls SNARE-mediated autophagosome fusion with a lysosome.

AUTOPHAGY, no. 5.0 (2015): 847.0-849

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Abstract

Autophagosome fusion with a lysosome constitutes the last barrier for autophagic degradation. It is speculated that this fusion process is precisely and tightly regulated. Recent genetic evidence suggests that a set of SNARE proteins, including STX17, SNAP29, and VAMP8, are essential for the fusion between autophagosomes and lysosomes. Ho...More

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