Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma.
Lung Cancer(2015)
摘要
•Use cobalt to create a hypoxic environment with upregulated HIF-1α.•Upregulation of HIF-1α leads to drug resistance and stemness.•Cell stemness can be evaluated by CD166.•CD166-positive cells showed solid drug resistance.•HIF-1α and CD166 may be a biomarker for prognosis in lung adenocarcinoma.
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关键词
Hypoxia,Lung adenocarcinoma,Cancer stem cells,Drug resistance,CD166
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