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Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.

BIOINFORMATICS, no. 20 (2014): 2906-2914

Cited: 103|Views43
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Abstract

Motivation: Imputation using external reference panels (e. g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop a new method for Gaussian imputation from summ...More

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