SPIO-coating of devices for MPI-guided cardiovascular interventions: Proof of principle

N Panagiotopoulos,Sjef Cremer,J Rahmer,Jochen Franke, R L Duschka,Sarah Vaalma,Michael Heidenreich,Jorn Borgert,Paul J A Borm,Jorg Barkhausen,Florian M Vogt,J Haegele

Magnetic Particle Imaging（2015）

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摘要

Initial studies have demonstrated that cardiovascular interventions should be feasible under MPI guidance with high temporal and sufficient spatial resolution. However, the interventional devices need to be visualized and must be safe. It is possible to visualize balloon-catheters for dilatation of vascular stenosis by filling their second lumen with a Resovist suspension[1], but this is not possible for diagnostic catheters and guide wires, as they possess only one or no lumen, respectively. The aim of this study was to develop a SPIO-based coating for visualization of Nitinol-based guide wires and diagnostic catheters, which have shown neither heating nor the occurrence of artifacts in MPI systems[2, 3].

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关键词

biomagnetism,biomedical imaging,biomedical materials,blood vessels,cardiovascular system,catheters,coatings,diseases,iron compounds,nickel alloys,superparamagnetism,titanium alloys,mpi-guided cardiovascular interventions,niti-fe2o3,nitinol-based guide wires,resovist suspension,spio-based coating,artifacts,balloon catheters,diagnostic catheters,heating,interventional devices,lumen,spatial resolution,temporal resolution,vascular stenosis dilatation

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