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Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97.

Proceedings of the National Academy of Sciences of the United States of America, no. 10 (2012): 3737-3741

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Abstract

Multimeric AAA ATPases represent a structurally homologous yet functionally diverse family of proteins. The essential and highly abundant hexameric AAA ATPase p97 is perhaps the best studied AAA protein, playing an essential role in various important cellular activities. During ATP-hydrolysis process, p97 undergoes dramatic conformational...More

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