Biodistribution of 137 Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system

The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137 Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l −1 . Ingestion started in parent animals before mating, and 137 Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137 Cs content was measured in various organs, indicating that 137 Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137 Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function.