Synaptic vesicle protein 2 enhances release probability at quiescent synapses

JOURNAL OF NEUROSCIENCE, pp. 1303-1313, 2006.

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Abstract:

We report a thorough analysis of neurotransmission in cultured hippocampal neurons lacking synaptic vesicle protein 2 (SV2), a membrane glycoprotein present in all vesicles that undergo regulated secretion. We found that SV2 selectively enhances low-frequency neurotransmission by priming morphologically docked vesicles. Loss of SV2 reduce...More

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