T1 mapping of the gadolinium-enhanced myocardium: adjustment for factors affecting interpatient comparison.
MAGNETIC RESONANCE IN MEDICINE(2011)
摘要
Quantitative T-1 mapping of delayed gadolinium-enhanced cardiac magnetic resonance imaging has shown promise in identifying diffuse myocardial fibrosis. Despite careful control of magnetic resonance imaging parameters, comparison of T-1 times between different patients may be problematic because of patient specific factors such as gadolinium dose, differing glomerular filtration rates, and patient specific delay times. In this work, a model driven approach to account for variations between patients to allow for comparison of T-1 data is provided. Kinetic model parameter values were derived from healthy volunteer time-contrast curves. Correction values for the factors described above were used to normalize T-1 values to a matched state. Examples of pre- and postcorrected values for a pool of normal subjects and in a patient cohort of type 1 diabetic patients shows tighter clustering and improved discrimination of disease state. Magn Reson Med 65:1407-1415, 2011. (C) 2010 Wiley-Liss, Inc.
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关键词
T-1 mapping,myocardial fibrosis,patient T-1 comparison,GFR,delayed enhancement
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