Comparison of Piperacillin Tazobactam and Cefoperazone Sulbactam Monotherapy in Treatment of Febrile Neutropenia

Monotherapy has tended to replace the combination therapy in emprical treatment of febrile neutropenia. There is no reported trial which compares the efficacy of cefoperazone‐sulbactam (CS) and piperacillin‐tazobactam (PIP/TAZO) monotherapies in the treatment of febrile neutropenia. In this prospective randomized study, we aimed to compare the safety and efficacy of CS versus PIP/TAZO as empirical monotherapies in febrile neutropenic children with cancer.