Myocardial perfusion, oxidative metabolism, and free fatty acid uptake in patients with hypertrophic cardiomyopathy attributable to the Asp175Asn mutation in the alpha-tropomyosin gene: a positron emission tomography study.

Helena Tuunanen,Johanna Kuusisto,Jyri Toikka,Pertti Jääskeläinen,Päivi Marjamäki,Keijo Peuhkurinen,Tapio Viljanen,Petri Sipola,Kira Q Stolen,Jarna Hannukainen,Pirjo Nuutila,Markku Laakso,Juhani Knuuti

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology（2007）

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摘要

In HCM attributable to the Asp175Asn mutation in the alpha-tropomyosin gene, myocardial oxidative metabolism and FFA metabolism are increased and inversely related to LV hypertrophy at both the whole heart and regional level. Increased metabolism and efficiency characterize patients with mild myocardial hypertrophy. These hypermetabolic alterations regress with advanced hypertrophy.

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关键词

hypertrophic cardiomyopathy,myocardial metabolism,positron emission tomography,efficiency

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