Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice.
JOURNAL OF CLINICAL INVESTIGATION, no. 5 (1999): 637-645
To understand the role of Na+/H+ exchanger 1 (NHE1) in intracellular pH (pH(i)) regulation and neuronal function, we took advantage of natural knockout mice lacking NHE1, the most ubiquitously and densely expressed NHE isoform in the central nervous system (CNS). CA1 neurons from both wildtype (WT) and NHE1 mutant mice were studied by con...更多
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