Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Joshua C Bis,Maryam Kavousi,Nora Franceschini,Aaron Isaacs,Gonçalo R Abecasis,Ulf Schminke,Wendy S Post,Albert V Smith,L Adrienne Cupples,Hugh S Markus,Reinhold Schmidt,Jennifer E Huffman,Terho Lehtimäki,Jens Baumert,Thomas Münzel,Susan R Heckbert,Abbas Dehghan,Kari North,Ben Oostra,Steve Bevan,Eva-Maria Stoegerer,Caroline Hayward,Olli Raitakari,Christa Meisinger,Arne Schillert,Serena Sanna,Henry Völzke,Yu-Ching Cheng,Bolli Thorsson,Caroline S Fox,Kenneth Rice,Fernando Rivadeneira,Vijay Nambi,Eran Halperin,Katja E Petrovic,Leena Peltonen,H Erich Wichmann,Renate B Schnabel,Marcus Dörr,Afshin Parsa,Thor Aspelund,Serkalem Demissie,Sekar Kathiresan,Muredach P Reilly,Kent Taylor,Andre Uitterlinden,David J Couper,Matthias Sitzer,Mika Kähönen,Thomas Illig,Philipp S Wild,Marco Orru,Jan Lüdemann,Alan R Shuldiner,Gudny Eiriksdottir,Charles C White,Jerome I Rotter,Albert Hofman,Jochen Seissler,Tanja Zeller,Gianluca Usala,Florian Ernst,Lenore J Launer,Ralph B D'Agostino Sr,Daniel H O'Leary,Christie Ballantyne,Joachim Thiery,Andreas Ziegler,Edward G Lakatta, Ravi Kumar Chilukoti,Tamara B Harris,Philip A Wolf,Bruce M Psaty,Joseph F Polak, Xia Li,Wolfgang Rathmann,Manuela Uda,Eric Boerwinkle,Norman Klopp,Helena Schmidt, James F Wilson,Jorma Viikari,Wolfgang Koenig, Stefan Blankenberg,Anne B Newman,Jacqueline Witteman,Gerardo Heiss,Cornelia van Duijn,Angelo Scuteri,Georg Homuth,Braxton D Mitchell,Vilmundur Gudnason,Christopher J O'Donnell

Nature Genetics（2011）

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摘要

Joshua Bis, Christopher O'Donnell and colleagues report a meta-analysis of genome-wide association studies from the CHARGE Consortium that identifies loci associated with carotid intima media thickness and plaque. These are established measures of subclinical atherosclerosis that predict future cardiovascular disease events.

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关键词

carotid intima media thickness,common variants,association,meta-analysis,genome-wide

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