A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

Simon N Stacey,Patrick Sulem,Aslaug Jonasdottir,Gisli Masson,Julius Gudmundsson,Daniel F Gudbjartsson,Olafur T Magnusson,Sigurjon A Gudjonsson,Bardur Sigurgeirsson,Kristin Thorisdottir, Rafn Ragnarsson,Kristrun R Benediktsdottir,Bjørn A Nexø,Anne Tjønneland,Kim Overvad,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Kari Hemminki,Cristina Corredera,Victoria Fuentelsaz, Pilar Grasa,Sebastian Navarrete,Fernando Fuertes,Maria D García-Prats,Enrique Sanambrosio,Angeles Panadero,Ana De Juan, Almudena Garcia,Fernando Rivera,Dolores Planelles,Virtudes Soriano,Celia Requena,Katja K Aben,Michelle M van Rossum,Ruben G H M Cremers,Inge M van Oort,Dick-Johan van Spronsen,Jack A Schalken,Wilbert H M Peters,Brian T Helfand,Jenny L Donovan,Freddie C Hamdy,Daniel Badescu,Ovidiu Codreanu,Mariana Jinga,Irma E Csiki,Vali Constantinescu,Paula Badea,Ioan N Mates, Daniela E Dinu,Adrian Constantin,Dana Mates, Sjofn Kristjansdottir,Bjarni A Agnarsson,Eirikur Jonsson,Rosa B Barkardottir,Gudmundur V Einarsson,Fridbjorn Sigurdsson,Pall H Moller,Tryggvi Stefansson, Trausti Valdimarsson,Oskar T Johannsson,Helgi Sigurdsson,Thorvaldur Jonsson,Jon G Jonasson,Laufey Tryggvadottir,Terri Rice,Helen M Hansen,Yuanyuan Xiao,Daniel H Lachance,Brian Patrick O′Neill,Matthew L Kosel,Paul A Decker,Gudmar Thorleifsson,Hrefna Johannsdottir,Hafdis T Helgadottir,Asgeir Sigurdsson,Valgerdur Steinthorsdottir,Annika Lindblom,Robert S Sandler,Temitope O Keku,Karina Banasik,Torben Jørgensen,Daniel R Witte,Torben Hansen,Oluf Pedersen,Viorel Jinga,David E Neal,William J Catalona,Margaret Wrensch,John Wiencke,Robert B Jenkins,Eduardo Nagore,Ulla Vogel,Lambertus A Kiemeney,Rajiv Kumar,José I Mayordomo,Jon H Olafsson,Augustine Kong,Unnur Thorsteinsdottir,Thorunn Rafnar,Kari Stefansson

NATURE GENETICS（2011）

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摘要

Simon Stacey, Kari Stefansson and colleagues show that a germline variant in the TP53 polyadenylation signal is associated with increased risk of basal cell carcinoma and other solid tumors.

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关键词

Cancer genetics,Genetic predisposition to disease,Genome-wide association studies,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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