Prediction of sustained response to low-dose pegylated interferon alpha-2b plus ribavirin in patients with genotype 1b and high hepatitis C virus level using viral reduction within 2 weeks after therapy initiation.

Hideyuki Tamai,Naoki Shingaki,Tatsuya Shiraki,Hiroshi Tukuda,Yoshiyuki Mori,Kosaku Moribata,Shotaro Enomoto,Hisanobu Deguchi,Kazuki Ueda,Izumi Inoue,Takao Maekita,Mikitaka Iguchi,Kimihiko Yanaoka,Masashi Oka,Masao Ichinose

HEPATOLOGY RESEARCH（2011）

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摘要

Aim: Continuation of pegylated interferon (PEG-IFN) plus ribavirin at the recommended dose is difficult in elderly patients and/or patients with cytopenia or complications. Whether the therapeutic efficacy of low-dose PEG-IFN plus ribavirin therapy could be predicted based on virological response within 2 weeks of therapy initiation was evaluated.

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关键词

genotype 1b,hepatitis C virus core antigen,hepatitis C virus-RNA,high viral load,viral kinetics

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