Condensed Chromatin Staining of CKAP2 As Surrogate Marker for Mitotic Figures
Journal of cancer research and clinical oncology(2011)
摘要
Proliferation activity has long been known to be one of the strongest prognostic factors in many different cancers. Nevertheless, microscopic evaluation of mitotic figures remains time-consuming and, furthermore, is relatively subjective. As the expression of cytoskeleton-associated protein 2 (CKAP2) is closely related to the mitotic phase, CKAP2 was evaluated as a surrogate mitotic figure (MF) marker.
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关键词
CKAP2,Breast cancer,Mitotic figure,Cell proliferation marker,Monoclonal antibody,Immunohistochemistry
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