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Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.

Christopher Sinz,Amy Bittner,Ed Brady,Mari Candelore,Qing Dallas-Yang,Victor Ding,Guoqiang Jiang,Zhen Lin,Sajjad Qureshi,Gino Salituro,Richard Saperstein,Jackie Shang,Deborah Szalkowski,Laurie Tota,Stella Vincent,Michael Wright,Shiyao Xu,Xiaodong Yang,Bei Zhang,James Tata,Ronald Kim,Emma R Parmee

Bioorganic & Medicinal Chemistry Letters（2011）

引用 11|浏览25
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摘要
hGCGR cAMP IC50=12nM, Active at 1mpk in an ob/ob/hGCGR, murine diabetes model.
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关键词
Glucagon,Diabetes,Glucose,Antagonist,Indole
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