Molecular profiling of common fragile sites in human fibroblasts

Benoî Le Tallec,Bernard Dutrillaux,Anne-Marie Lachages,Gael Armel Millot,Olivier Brison,Michelle Debatisse

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2011）

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摘要

Common fragile sites (CFSs) can drive genomic instability. The basis for their fragile nature is not clear, but lymphocyte CFSs have been mapped to regions with low replication initiation events and late replication completion. These features are now used to rapidly identify CFSs in different fibroblast cells.

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nature structural and molecular biology, science

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