Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis
Translational Research（2021）
关键词
ADA = adalimumab,ANOVA = analysis of variance,bDMARDs = biological disease-modifying anti-rheumatic drugs,BsAb = bispecific antibody,cDNA = complementary DNA,CXCL10 = C-X-C motif chemokine 10,FLS = fibroblast-like synoviocytes,GAPDH = glyceraldehyde 3-phosphate dehydrogenase,H&E = hematoxylin and eosin,IC50 = the half-maximal inhibitory concentration,IL = interleukin,Kd = dissociation constants,LPS = lipopolysaccharide,Mw = molecular weight,O.D. = optical density,PBMCs = peripheral blood mononuclear cells,PBS = phosphate-buffered saline,qPCR = quantitative real-time polymerase chain reaction,RA = rheumatoid arthritis,RANKL = receptor activator of nuclear factor kappa-B ligand,ScFv = single-chain variable fragment,SEM = standard error of the mean,SPR = surface plasmon resonance,Tg mouse = transgenic mouse,TNF-α = tumor necrosis factor-α,TRAP = tartrate-resistant acid phosphatase,VH = variable heavy chain,VL = variable light chain
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