Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.

Thaís Moreira Osório,Franco Delle Monache,Louise Domeneghini Chiaradia,Alessandra Mascarello,Taisa Regina Stumpf,Carlos Roberto Zanetti,Douglas Bardini Silveira,Célia Regina Monte Barardi, Elza de Fatima Albino Smânia,Aline Viancelli,Lucas Ariel Totaro Garcia,Rosendo Augusto Yunes,Ricardo José Nunes,Artur Smânia

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

Sixty-five synthetic or natural chalcones, hydrazones and oxadiazoles were assayed against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus (MRSA) isolates. Two chalcones, one dihydrochalcone and two hydrazones showed important activity against MRSA and are promising as antibiotic-like substances.

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关键词

MRSA,Chalcones,Hydrazones,Oxadiazoles,Antibacterial activity,Cytotoxic activity,PCR and RAPD

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