Levetiracetam reverses synaptic deficits produced by overexpression of SV2A

PloS one, Volume 6, Issue 12, 2011, Pages e29560-e29560.

Cited by: 28|Views0
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Abstract:

Levetiracetam is an FDA-approved drug used to treat epilepsy and other disorders of the nervous system. Although it is known that levetiracetam binds the synaptic vesicle protein SV2A, how drug binding affects synaptic functioning remains unknown. Here we report that levetiracetam reverses the effects of excess SV2A in autaptic hippocampa...More

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