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The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

Janine M van Gils,Merran C Derby,Luciana R Fernandes,Bhama Ramkhelawon,Tathagat D Ray,Katey J Rayner,Sajesh Parathath,Emilie Distel,Jessica L Feig,Jacqueline I Alvarez-Leite,Alistair J Rayner,Thomas O McDonald,Kevin D O'Brien,Lynda M Stuart,Edward A Fisher,Adam Lacy-Hulbert,Kathryn J Moore

NATURE IMMUNOLOGY（2012）

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摘要
Lipid-engorged macrophages accumulate in atherosclerotic plaques where chronic inflammation ensues. Moore and colleagues show that macrophage migration to chemokines and egress is arrested by netrin-1, which is secreted in the plaque lesions.
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关键词
atherosclerosis,macrophages,plaques
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