Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.

Vadim Y Dudkin,Cheng Wang,Kenneth L Arrington,Mark E Fraley,George D Hartman,Steven M Stirdivant,Robert A Drakas,Keith Rickert,Eileen S Walsh,Kelly Hamilton,Carolyn A Buser,James Hardwick,Weikang Tao,Stephen C Beck,Xianzhi Mao,Robert B Lobell,Laura Sepp-Lorenzino

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

The optimization of selectivity and physical properties of pyridyl aminothiazole series of Chk1 inhibitors aimed at improving cellular activity levels is described.

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