IL-36 a new member of the IL-1 family cytokines.

D Tripodi,F Conti,M Rosati,G Maccauro,A Saggini,E Cianchetti,D Angelucci,M Fulcheri,S Tetè,V Salini,A Caraffa,P Antinolfi,E Toniato,M L Castellani,P Conti,T C Theoharides

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS（2012）

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摘要

Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36 activates MAPK and NF-KB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. Here we summarise and review the new aspects of this important pro-inflammatory cytokine.

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关键词

IL-36,cytokines,interleukins,inflammation,immunity

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