Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura

Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura . Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J -based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus , Candida albincans and Kluyveromyces fragilis .