Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.
Mark L Boys,Feng Bian,James B Kramer,Christopher L Chio,Xiao-Dan Ren,Huifen Chen,Stephen Douglas Barrett,Karen Elaine Sexton,Donna M Iula,Gary F Filzen,Maria N Nguyen,Paul Angell,Victoria L Downs,Zhi Wang,Neil Raheja,Edmund L Ellsworth,Stephen Alan Fakhoury,Larry D Bratton,Paul R Keller,Richard Gowan, Elena M Drummond,Samarendra N Maiti,Mostofa A Hena, Leroy Lu,Patrick McConnell,John D Knafels,Venkataraman Thanabal,Fang Sun, Diane Alessi, Ann McCarthy,Erli Zhang,Barry C Finzel, Sneha Patel,Susan M Ciotti,Rone Eisma, N A Payne, Richard B Gilbertsen, Catherine R Kostlan,David J Pocalyko,Deepak S Lala Bioorganic & Medicinal Chemistry Letters（2012）
摘要
Application of PF-03671148 to rat wounds leads to a dose dependent inhibition of multiple fibrotic genes in vivo.
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关键词
Activin receptor-like Kinase 5,Transforming growth factor beta,Topical,Dermal scarring,Wound repair
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