Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers.

Eleonora L Swart,Ben van der Hoven,A B Johan Groeneveld,Daniel J Touw,Meindert Danhof

British journal of clinical pharmacology（2002）

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摘要

It is concluded that there is a significant correlation between lignocaine and midazolam clearances but this correlation is lost after CYP3A4 inhibition by erythromycin. The MEGX-test is of no value in assessing intra- and inter-individual variability in midazolam clearance.

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