Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method

PloS one, Volume 7, Issue 5, 2012, Pages e36888-e36888.

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Keywords:
computational biologybayes theoremsingle nucleotide polymorphismgenome wide association studystatistical powerMore(3+)

Abstract:

Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by incorporating complementary data. In this study we investigated the feasibility of automatically retrieving information from the medical literature and leveraging this information in GWAS....More

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