Assessment of Response of Brain Metastases to Radiotherapy by PET Imaging of Apoptosis with 18F-ML-10

Aaron M. Allen,Miri Ben-Ami,Ayelet Reshef,Adam Steinmetz,Yulia Kundel,Edna Inbar,Ruth Djaldetti,Tal Davidson,Eyal Fenig,Ilan Ziv

European journal of nuclear medicine and molecular imaging（2012）

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摘要

Early assessment of tumor response to therapy is vital for treatment optimization for the individual cancer patient. Induction of apoptosis is an early and nearly universal effect of anticancer therapies. The purpose of this study was to assess the performance of 18F-ML-10, a novel PET radiotracer for apoptosis, as a tool for the early detection of response of brain metastases to whole-brain radiation therapy (WBRT).

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关键词

Positron emission tomography,Response assessment,Whole-brain radiation therapy,Brain metastases,Apoptosis

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