Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain.

Yvonne Hoehna,Ortrud Uckermann,Hella Luksch,Vanya Stefovska,Jenny Marzahn,Marlen Theil,Tomasz Gorkiewicz,Maciej Gawlak,Grzegorz M Wilczynski,Leszek Kaczmarek,Chrysanthy Ikonomidou

Neurobiology of Disease（2012）

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摘要

Matrix metalloproteinases (MMPs) are involved in tissue repair, cell death and morphogenesis. We investigated the role of the gelatinases MMP-2 and MMP-9 in the pathogenesis of neuronal death induced by prolonged seizures in the developing brain.

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关键词

Development,Seizure,Cell death,Gelatinase,MMP

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