Telomeres and chromosomal instability in chronic lymphocytic leukemia
LEUKEMIA(2012)
摘要
Telomeres are protective chromosomal end structures composed of G-rich nucleotide repeats and an associated protein complex termed shelterin. Because of incomplete replication, telomeric repeats are lost with every cell division, and this telomere attrition is involved in cell senescence and cancer (reviewed in Artandi and DePinho1).
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关键词
LEU, oncology, haematology, immunology, leukemia, stem cells, oncogenes, growth factors, apoptosis, therapy, fusion genes, lymphoma, hemopoiesis
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