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Genetic Code Ambiguity - Cell Viability Related To Severity Of Editing Defects In Mutant Trna Synthetases

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 48 (2002): 45729-45733

Cited: 89|Views26
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Abstract

The rules of the genetic code are established in reactions that aminoacylate tRNAs with specific amino acids. Ambiguity in the code is prevented by editing activities whereby incorrect aminoacylations are cleared by specialized hydrolytic reactions of aminoacyl tRNA synthetases. Whereas editing reactions have long been known, their signif...More

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