Histologic-genetic mapping by allele-specific PCR reveals intraurothelial spread of p53 mutant tumor clones
LABORATORY INVESTIGATION, pp. 1553-1561, 2002.
Common and clinically important features of urothelial carcinomas are multifocality and a high rate of recurrence. Molecular studies demonstrated that multifocal tumors are frequently composed of one tumor clone spreading throughout the urothelial tract. A combination of histologic and genetic mapping of cystectomy specimens from bladder ...More
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