Infliximab In Primary Sjogren'S Syndrome - One-Year Followup

Objective. To evaluate the safety and efficacy of a maintenance regimen of infliximab in patients with active primary Sjogren's syndrome (SS) over a 1-year period.Methods. This followup study included 10 of the 16 patients with primary SS who participated in a pilot study. Patients who continued to have symptoms received additional infusions of infliximab for 1 year.Results. All patients completed the 1-year followup for evaluation of efficacy. After 1 year, a statistically significant decrease in global and local disease manifestations was observed in all 10 patients. Treatment was generally well tolerated, with the main side effect being a mild, self-limited infusion reaction.Conclusion. Sustained improvement of active primary SS may be possible with infliximab treatment.