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Fetal Origins Of Hematopoietic Failure In A Murine Model Of Fanconi Anemia

BLOOD, no. 11 (2013): 2008-2012

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Abstract

Hematopoietic failure is the predominant clinical manifestation of Fanconi anemia (FA), a rare, recessively inherited disorder. Mutations in 1 of 15 genes that coordinately function in a complex pathway to maintain DNA integrity also predispose patients to constitutional defects in growth and development. The hematologic manifestations ha...More

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