Activation of Rac1 GTPase by nanoparticulate structures in human macrophages.

Britta Diesel,Jessica Hoppstädter,Nina Hachenthal,Robert Zarbock,Christian Cavelius,Birgit Wahl,Nicolas Thewes,Karin Jacobs,Annette Kraegeloh,Alexandra K Kiemer

European Journal of Pharmaceutics and Biopharmaceutics（2013）

引用 17|浏览2

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摘要

Activation of macrophages via Toll--like receptor 9 requires two hits: nanoparticulate matter induces Rac1-dependent reorganization of the cytoskeleton whereas receptor-specific ligands synergistically induce inflammatory cell responses.

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关键词

Immune stimulatory sequence,Silica nanoparticles,Actin polymerization,Small Rho GTP-ases,Atomic force microscopy,CLSM

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