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Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution.

Trends in Genetics, no. 6 (2013): 358-366

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The premise of genetic analysis is that a causal link exists between phenotypic and allelic variation. However, it has long been documented that mutant phenotypes are not a simple result of a single DNA lesion, but are instead due to interactions of the focal allele with other genes and the environment. Although an experimentally rigorous...更多

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