Extracellular NAADP affords cardioprotection against ischemia and reperfusion injury and involves the P2Y11-like receptor.

Zoubir Djerada,Hélène Peyret,Sylvain Dukic,Hervé Millart

Biochemical and Biophysical Research Communications（2013）

引用 24|浏览8

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摘要

•Extracellular NAADP promotes cardiac preconditioning via the P2Y11-like receptors.•P2Y11-like receptors are able to induce prosurvival kinase activation in rat cardiomyocyte.•NAADP is released during ischemia suggesting a paracrine survival role.

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关键词

I/R,LVEDP,NAADP,pEC50,RPP,VF,VT

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