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N-Bridged Bicyclic Sulfonamides As Inhibitors of Gamma-Secretase

Simeon Bowers,Gary D. Probst,Anh P. Truong,Roy K. Hom,Andrei W. Konradi,Hing L. Sham,Albert W. Garofalo,Karina Wong,Erich Goldbach,Kevin P. Quinn,John-Michael Sauer,William Wallace,Lan Nguyen,Susanna S. Hemphill,Michael P. Bova,Guriqbal S. Basi

Bioorganic & medicinal chemistry letters（2009）

Cited 10|Views3
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Abstract
The structural modification of a series of [3.3.1] bicyclic sulfonamide based gamma-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.
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Key words
Alzheimer's disease,gamma-Secretase inhibitor,Bicyclic sulfonamides
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