New PI(4,5)P2- and Membrane Proximal Integrin–binding Motifs in the Talin Head Control Β3-Integrin Clustering

A talin intermolecular interaction autoinhibits its own activation and regulates β3-integrin binding. When bound, β3-integrin undergoes structural alterations that prevent its β and α subunits from associating, maintaining β3-integrin's clustering capability.