Backbone cyclic helix mimetic of chemokine (C-C motif) receptor 2: a rational approach for inhibiting dimerization of G protein-coupled receptors.

Mattan Hurevich,Maya Ratner-Hurevich,Yftah Tal-Gan,Deborah E Shalev,Shlomo Z Ben-Sasson,Chaim Gilon

Bioorganic & Medicinal Chemistry（2013）

引用 13|浏览11

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摘要

‘Helix walk’ enables helix mimetic of CCR2 dimerization region by urea backbone cyclization.

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ACN,BBB,Boc,BTC,CCR2,CCR5,CNS,DIPEA,DMF,N,ESI,EtOAc,Fmoc,GPCR,HATU,HBTU,HOAt,HOBt,HRMS,MALDI,MAPS,MBHA,NMP,NMR,NOESY,OSu,Pbf,PFPC,ROESY,RP-HPLC,SPPS,tBu,TDW,TFA,TFE,TLC,TM-1,TOCSY,TOF

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