In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates.

Xin Li,Kai Wang,Wei Wei,Yong-yu Liu,Lu Gong

Chemico-Biological Interactions（2013）

引用 26|浏览1

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摘要

•Brucine has the potential to interact with CYP3A4 substrates.•Brucine can inhibit the activity of CYP3A4.•The enzyme kinetics of brucine in HLMs and CYP3A4 follow Michaelis–Menten kinetics.

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关键词

Brucine,Human liver microsome,CYP3A4,Metabolism,Interaction

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