Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells.

Ann-Jeng Liu,Sheng-Hao Wang,Ku-Chung Chen,Hsiu-Ping Kuei,Yung-Luen Shih,Sz-Ying Hou,Wen-Ta Chiu,Sheng-Huang Hsiao,Chwen-Ming Shih

Chemico-Biological Interactions（2013）

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摘要

•Evodiamine induced a survival function of autophagy in human glioma cells.•Evodiamine-induced autophagy and apoptosis may result from calcium releasing from ER.•Evodiamine induced a calcium/JNK-mediated autophagy.

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关键词

2-APB,3-MA,AIF,AVO,[Ca2+]i,Evo,JC-1,LC3,FITC,PI,ROS

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