Interleukin-6 upregulates paraoxonase 1 gene expression via an AKT/NF-κB-dependent pathway.

Chi-Chih Cheng,Chi-Mei Hsueh,Chiu-Yuan Chen,Tzu-Hsiu Chen,Shih-Lan Hsu

Biochemical and Biophysical Research Communications（2013）

引用 21|浏览5

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摘要

•IL-6 could induce PON1 gene expression.•IL-6 increased NF-κB protein expression and NF-κB-p50 and -p65 subunits nuclear translocation.•IL-6-induced PON1 up-regulation was through an AKT/NF-κB pathway.

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关键词

Paraoxonase 1,Interleukin-6,AKT,NF-κB,Atherosclerosis

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