Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia.

•Social approach behavior was not disrupted by NMDA antagonists.•The disruption induced by d-amphetamine was variable and was not reversed by antipsychotics.•The GABAA inverse agonist, FG-7142 induced a robust and reliable disruption of social behavior.•In line with clinical efficacy against negative symptoms, d-cycloserine reversed the FG-7142-induced deficit.•These data suggest FG-7142 disruption of social approach is a useful model for negative symptoms of schizophrenia.